How many ml of benadryl should a 220 lb man take for yellow jacket stings?

For treating allergic reactions such as yellow jacket stings, the typical adult dosage of Benadryl (diphenhydramine) is 25 to 50 mg every 4 to 6 hours, not exceeding 300 mg in 24 hours. Since the weight of the individual (220 lbs) does not significantly change the standard dosing guidelines, he should take the regular adult dose. However, it's essential for him to consult a healthcare professional for personalized advice, especially if he has any pre-existing health conditions or is taking other medications.