How phenylketonuria causes eczema?

Phenylketonuria (PKU) is a genetic disorder characterized by the inability to metabolize phenylalanine, an amino acid. The accumulation of phenylalanine and its byproducts can lead to various neurological and metabolic issues, potentially triggering inflammatory responses in the skin. This inflammation may manifest as eczema, a condition marked by dry, itchy, and inflamed skin. Additionally, dietary restrictions in PKU can lead to nutritional deficiencies that may exacerbate skin conditions like eczema.