Gender dysphoria is the clinical term for the idea espoused by transsexuals, namely that they mentally self-perceive as the gender opposite their physical nature. (I.e. a male that sees himself as a girl or a female that sees herself as a boy.)
Islam overwhelmingly condemns transsexual behaviors and activities. In Islam, a person experiencing gender dysphoria would be expected to try to "get cured" of the condition through both religious practice and psychological help.
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