What are the possible hazards of bioaccumulation?

OK well *The deaths of many large sea mammals such as dolphins and whales, which is thought to be related to bio accumulation
*The thinning of egg shells of birds such as the American Eagle, leading to this animal becoming endangered
*increased rates of cancer, disease and deformities in humans
and
*increased rates of death and disease in many animals, especially the top predators, such as polar bears. :)