How can you get from fort Myers FL to naples FL?

To get from Fort Myers, FL to Naples, FL, you can take Interstate 75 South (I-75 S), which is the most direct route. The drive typically takes about 30-40 minutes, depending on traffic. Alternatively, you can take U.S. Route 41 (Tamiami Trail) for a more scenic route along the coast. Both options are straightforward and well-marked.