After ten years of depo can you get pregnant?

Yes, but your actual fertility is unpredictable. Depo-provera or medroxyprogeterone acetate is an injectable progesterone. Each shot is roughly effective for 3 months. Depo-provera prevents the proliferation of your endometrium (the lining of your uterus) which means that your periods may become lighter or stop altogether. However, this is not a permenant change. Eventually, the levels of depo-provera will drop no matter how long you have been on it and you will be able to get pregnant again. This is preventable by continuing to receive shots at a regular 3 month interval. As with any form of contraception, it is not 100% effective so it is important to remember that you could become pregnant at anytime although it is unlikely.