Which disease caused by deficiency of niacin?

Pellagra

is a

vitamin

deficiency diseasemost commonly caused by a chronic lack of

niacin(vitamin B

3) in the diet. It can be caused by decreased intake of niacin or

tryptophan,

and possibly by excessive intake of

leucine.

It may also result from alterations in protein metabolism in disorders such as

carcinoid syndrome.

Pellagra is classically described by "the four D's": diarrhea,dermatitis,dementiaanddeath.A more comprehensive list of symptoms includes:

• Highsensitivity to sunlight
• Aggression
• Dermatitis,alopecia,edema
• Smooth, beefy redglossitis
• Redskin lesions
• Insomnia
• Weakness
• Mental confusion
• Ataxia, paralysis of extremities, peripheral neuritis
• Diarrhea
• Dilated cardiomyopathy
• Eventuallydementia

Frostig and Spies (acc. to Cleary and Cleary) described more specific psychological symptoms of pellagra as:]

• Psychosensory disturbances (impressions as being painful, annoying bright lights, odors intolerance causing nausea and vomiting, dizziness after sudden movements)

• Psychomotor disturbances (restlessness, tense and a desire to quarrel, increased preparedness for motor action)

• Emotional disturbances