When did the first major wave of European immigration start?

The first major wave of European Immigration to the United States began in the mid-19th century, particularly around the 1840s and 1850s. This period was characterized by large influxes of Irish and German immigrants, driven by factors such as famine, political unrest, and economic opportunities. The Irish Potato Famine (1845-1852) significantly contributed to the surge, leading to millions seeking a better life in America.