How many times have they sent astronauts into space?

As of October 2023, astronauts have been sent into space thousands of times since the first human spaceflight in 1961. The exact number varies depending on how one counts missions, but notable examples include the Apollo missions, Space Shuttle flights, and various missions to the International Space Station (ISS). Each of these programs has contributed significantly to the total count of human spaceflights. Overall, over 600 individuals have traveled to space on various missions.