Knee cortisone shots can cause some discomfort during and after the injection, often described as a brief sharp pain or pressure. The level of pain varies from person to person, depending on individual pain tolerance and the specific technique used by the healthcare provider. Many patients find that any initial discomfort is outweighed by the relief from inflammation and pain that follows. After the injection, some mild soreness may occur, but this typically subsides within a few days.
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