How do you get from Houston to Memphis by road?

To drive from Houston to Memphis, take I-10 East from Houston and then merge onto I-20 East toward Monroe, Louisiana. Continue on I-20 until you reach Jackson, Mississippi, where you'll switch to I-55 North. Follow I-55 directly to Memphis, which is approximately a 600-mile journey that typically takes around 8 to 10 hours, depending on traffic and road conditions.