The most sedating antipsychotic is often considered to be clozapine, particularly due to its strong sedative effects. Other highly sedating options include quetiapine and olanzapine. These medications are used to manage symptoms of schizophrenia and Bipolar disorder but can cause significant drowsiness, which may be beneficial for patients with severe agitation or insomnia. However, their sedative properties can also lead to challenges in daily functioning.
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