What are the causes of macroangiopathy?

Macroangiopathy is primarily caused by atherosclerosis, which is the buildup of plaque in the large blood vessels, leading to reduced blood flow. Risk factors include Diabetes, hypertension, high cholesterol, smoking, and obesity. Chronic inflammation and endothelial dysfunction also play significant roles in the development of macroangiopathy. These factors contribute to the thickening and hardening of arterial walls, increasing the risk of cardiovascular events.