What major artery supplies the heart itself blood?

The coronary arteries. These leave the aorta and branch out over the heart. Blood only flows though these vessels during diastole because during systole they are blocked off by the aortic valve.

The two main vessels that arise from the Sinus of Valsalva, located just above the aortic valves, are the right and left cornary arteries. The right coronary artery mainly supply the right ventricle and the sinoatrial node. The left main artery is divided into the left anterior descending artery and the left circumflex artery. The left anterior descending artery mainly supplies the anterior and septal portion of the heart, namely the left ventricle. The left circumflex artery supplies the lateral walls of the left ventricle. Finally, the posterior descending artery can arise from either the right or left coronary artery. If the posterior descending artery arises from the right coronary artery, the heart is termed right heart dominant, which is seen in approximately 70% of individuals. If the posterior descending artery arises from the left circumflex artery, it is termed left heart dominance. It is also possible for the posterior descending artery to arise from both the right and left coronary artery. In this configuration, the heart is considered co-dominant. The posterior descending artery mainly supplies the inferior wall of the left ventricle and the inferior portion of the septal wall.