Yes, a .44 Magnum handgun can potentially kill a grizzly bear if the shooter is skilled and delivers a well-placed shot. The .44 Magnum has sufficient stopping power, especially with the right type of ammunition designed for large game. However, it's important to note that hunting or confronting grizzly bears poses significant risks, and using a handgun for such situations should only be done by experienced individuals in compliance with local laws and regulations.
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