How many miles from ft.Myers FL. to key west FL.?

The total driving distance from Fort Myers, FL to Key West, FL is 302 miles.

1. Take I-75 SOUTH (towards NAPLES) from Ft Myers to Florida's TURNPIKE (toll) - SOUTH to KEY WEST at EXIT 5. Please note that I-75 thru the Everglades (past Naples) is ALLIGATOR ALLEY, which is a toll road.
2. Take the TURNPIKE (toll) - SOUTH to U.S. 1 SOUTH to HOMESTEAD (and KEY WEST) at the END of the Turnpike in Homestead.
3. Take U.S. 1 SOUTH to Key West.