How is Marfan syndrome is inherited?

Marfan syndrome is inherited in an autosomal dominant manner, which means that only one copy of the mutated gene from an affected parent can cause the condition in their offspring. This disorder is primarily caused by mutations in the FBN1 gene, which encodes the protein fibrillin-1, essential for connective tissue integrity. Individuals with Marfan syndrome have a 50% chance of passing the mutation to each child. Since it is dominant, the severity of the condition can vary widely among affected individuals.