How does marfan's syndrome cause aneurysms?

Marfan's syndrome is a genetic disorder that affects connective tissue, leading to structural weaknesses in the cardiovascular system. One of the most significant consequences is the weakening of the aorta's walls, making them more prone to dilation and aneurysm formation. This occurs due to abnormalities in the fibrillin-1 protein, which is crucial for maintaining the elasticity and integrity of connective tissues. As the aorta becomes weaker and dilates, the risk of aneurysm and potential rupture increases, posing serious health risks.