Hernando de Soto's exploration in the 16th century had significant consequences for indigenous populations in the southeastern United States. His expedition led to the violent subjugation and exploitation of Native American tribes, resulting in loss of life, territory, and resources. De Soto's encounters also facilitated the spread of European diseases, which devastated native communities lacking immunity. Furthermore, his explorations contributed to European interest in the region, paving the way for further colonization and the eventual displacement of indigenous peoples.
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