What major highways or interstates go north and south of Washington?

Major highways that run north and south of Washington, D.C., include Interstate 95 (I-95), which connects the city to the northeast and southeast regions of the United States. Additionally, Interstate 295 (I-295) serves as a bypass around the city, linking I-95 and I-66. U.S. Route 1 also provides a north-south corridor through the area. These routes facilitate travel to various destinations along the eastern seaboard.