Are masses like grams and kilograms always the easiest way to measure chemical quantities?

Masses like grams and kilograms are commonly used to measure chemical quantities due to their straightforwardness and direct relationship to the amount of substance. However, in certain contexts, such as in reactions involving gases or solutions, using moles (which relate to the number of particles) can be more practical because they account for the stoichiometry of reactions. Additionally, measuring in terms of volume (liters, milliliters) can be more convenient for liquids. Thus, while mass is often used, it may not always be the easiest or most effective measurement for every chemical scenario.