What does the title The Most Dangerous Game mean?

The title is a play on the Word game which can mean a challenge or sport. It can also mean hunted animals. In the short story (set in the 1920s), the "most dangerous game" is both.

On his mysterious Caribbean island, Russian expatriate General Zaroff has taken to a different kind of hunting -- hunting men -- mostly shipwrecked sailors who he captures and then kills, ostensibly having given them a chance to escape by eluding him. A marooned big game hunter inadvertently becomes the prey and must turn the tables on Zaroff to survive.