Odd numbered interstate highways run in what two directions?

Odd numbered one and two digit interstates usually run north and south, although I-69 north of Lansing is signed as east-west. Three digit interstates are auxiliary routes and are therefore based on the direction they are going. For example, Interstate 35 itself goes north-south, but I-435 goes east-west, then turns and becomes north-south, then becomes east-west again, completing it's beltway in that fashion, intersecting I-35 twice (once in the north and once in the south).