Take I-74 EAST to I-275 SOUTH to Kentucky at EXIT 5 in Ohio outside of Cincinnati.
Take I-275 around Cincinnati to I-75 SOUTH at EXIT 84 in northern Kentucky.
Take I-75 SOUTH to Punta Gorda. A few bypasses that you need to worry about on I-75: the first one is of Atlanta, Georgia via I-285 WEST BYPASS (EXIT 259 off I-75, then EXIT 58 off I-285 to get back onto I-75 SOUTH and the second one is of Macon, Georgia via I-475 SOUTH (EXIT 177 of I-75).