What is the best way of controleing the pain from osteoathritis?

The best way is lifestyle - non-impact exercise and weight loss.

The least toxic medication is Tylenol (acetominophen), limited to 2000-3000 mg per day (the 4000mg max dose listed on the bottle can be toxic).

Anti-inflammatories such as Motrin, Advil, and Aleve are effective but can cause bleeding, stomach problems and kidney problems.