What does desean mean in spanish?

You [or He or She] would like is one English equivalent of 'desea'. It's the verb form for the second person singular formal 'you' or third person singular 'he/she/it'. Either way, it's pronounced 'deh-SEH-ah'.

Desire! is another equivalent. It's the imperative form of the infinitive 'desear'. It's the command form of the verb for the second person singular informal 'you'.