What might happen if buffers did not exist within human body?

If buffers did not exist in the human body, the pH levels of blood and other bodily fluids would fluctuate dramatically in response to metabolic processes. This could lead to acidosis or alkalosis, both of which can disrupt cellular function and impair essential physiological processes. Without the stabilizing effect of buffers, enzyme activity, oxygen transport, and nutrient absorption would be severely compromised, potentially resulting in serious health issues or even death.