What significant event in history involved Martin Luther and the act of nailing his 95 Theses to the door of a church?

The significant event in history involving Martin Luther was the Protestant Reformation, which began when he nailed his 95 Theses to the door of the Castle Church in Wittenberg, Germany in 1517. This act challenged the Catholic Church's practices and beliefs, leading to a split in Christianity and the formation of Protestantism.