Is it safe to take 2mg xanax with 5mg vicodin?

If you've taken Xanax or Hydrocodone before and know how it affects you and you can easily handle 2mg of xanax , you could take both an be fine. The only worry would be if you increased these amounts, which could result in CNS depression or serious overdose. (Depending on your tolerance) But the rule of thumb would be not to mix downers. Oh, And don't drink. That's a big NONO, ESPECIALLY when mixing an already potentially dangerous concoction ofpharmaceuticals.