What were the Indians disadvantages vs europeans?

Indigenous peoples in the Americas faced several disadvantages against Europeans, primarily due to the latter's advanced military technology, such as firearms and cannons, which were far superior to the traditional weapons used by Native Americans. Additionally, Europeans brought with them diseases like smallpox, which devastated Indigenous populations who had no immunity. The Europeans' organized political structures and strategies also allowed for more coordinated military campaigns, further compounding the challenges faced by Indigenous groups. Lastly, the divisions among various tribes often hindered unified resistance against European encroachment.