What disease nearly wiped out the entire tribe of Mandan Indians?

The disease that nearly wiped out the entire tribe of Mandan Indians was smallpox. In the early 1830s, an outbreak of smallpox decimated the population, leading to a significant decline in their numbers. The Mandan, already weakened by previous diseases and conflicts, suffered devastating losses, with estimates suggesting that up to 90% of the tribe perished. This tragic event significantly impacted their culture and way of life.