How is Zoloft metabolized and excreted?

Zoloft (sertraline) is primarily metabolized in the liver through the cytochrome P450 enzyme system, particularly CYP2B6 and CYP2C19. Its metabolites are further conjugated and then excreted mainly through the urine. A smaller portion is eliminated in feces. The drug's half-life is approximately 24 hours, which supports once-daily dosing.