Can Xbox 1 players play with PC players overwatch?

Yes, Xbox One players can play with PC players in Overwatch, but only if the game is set to allow cross-play. Cross-play is available in Overwatch, but players on Xbox will be matched with others on consoles, while PC players will generally be matched with each other due to differing input methods. However, if players are grouped together in a party, they can play against each other across platforms.