Loss of caudate and putamen cells in huntingtons disease?

In Huntington's disease, the progressive loss of neurons in the caudate nucleus and putamen, which are parts of the basal ganglia, leads to motor, cognitive, and psychiatric symptoms. This degeneration is primarily due to a genetic mutation in the HTT gene, resulting in the production of toxic huntingtin protein. The loss of these neurons disrupts normal movement control and contributes to the characteristic chorea and other motor dysfunctions associated with the disease. Ultimately, this neuronal loss significantly impacts the overall functioning of the basal ganglia circuitry.