In the history of the ncaa tournament has number 1 ever lost in the first round?

Yes, in NCAA tournament history, a number 1 seed has lost in the first round only once. This historic upset occurred in 2012 when the University of Virginia was defeated by 16th-seeded University of Maryland, Baltimore County (UMBC). This game marked a significant moment in College Basketball history, as it was the first time a 16 seed triumphed over a 1 seed in the tournament's history.