What is half life of methotrexate?

The half-life of methotrexate varies depending on the dose and the route of administration, but it typically ranges from 3 to 10 hours in patients receiving low-dose therapy. In cases of high-dose methotrexate, the half-life can be prolonged, sometimes extending to 8 to 15 hours or longer. Factors such as kidney function and hydration status can also influence the drug's half-life.