Will a 2015 ford f250 grill fit a 2001 ford f250?

No, a 2015 Ford F250 grill will not fit a 2001 Ford F250. The design, mounting points, and dimensions of the grills for these two model years are different due to updates in styling and body design. If you're looking to replace or upgrade the grill, it's best to find one that matches the specific model year.