Whats a mechanism that would allow insulin to open a pore?

Insulin opens a pore, specifically in the context of glucose uptake, primarily through its interaction with insulin receptors on cell membranes. When insulin binds to its receptor, it triggers a signaling cascade involving the activation of the insulin receptor substrate (IRS) and subsequent pathways like the PI3K/Akt pathway. This signaling promotes the translocation of glucose transporter proteins, such as GLUT4, to the cell membrane, effectively creating a pore through which glucose can enter the cell.