What is the best route between Yuma AZ and Spokane WA?

The best route from Yuma, AZ, to Spokane, WA, typically involves taking I-10 W from Yuma to I-15 N in California, then merging onto I-90 W toward Spokane. This route covers approximately 1,300 miles and offers a mix of desert and mountainous scenery. It's advisable to check for road conditions and potential weather impacts, especially in mountainous areas. Consider planning stops in major cities along the way for rest and food.