No, you cannot safely shoot a .300 Savage cartridge from a .308 rifle. While both cartridges have similar bullet diameters, the .300 Savage operates at a higher pressure level than the .308 Winchester. Firing a .300 Savage cartridge from a .308 rifle could result in dangerous overpressure situations, potentially causing damage to the firearm and posing a risk to the shooter. It is crucial to always use the correct ammunition specified by the firearm manufacturer.
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