What is the fastest driving route from morehead KY to Hilton head island sc?

The fastest driving route from Morehead, KY, to Hilton Head Island, SC, typically involves taking I-64 E to I-75 S, then merging onto I-16 E toward Savannah. From there, you would take US-278 E directly to Hilton Head Island. The journey covers approximately 550 miles and usually takes around 8-9 hours, depending on traffic conditions. Always check a navigation app for real-time updates and alternative routes.