How would the US be different today if the Jamestown settlement disappeared like the Roanoke settlement?

If the Jamestown settlement disappeared like the Roanoke settlement, the early English attempts to establish a permanent colony in America would have likely failed, impacting the future colonization efforts in the region. The absence of Jamestown could have altered the balance of power in North America, potentially leading to different European nations dominating different regions. This could have drastically changed the course of American history, including the trajectory of European settlement, Native American interactions, and ultimately the formation of the United States.