Is it safe to take lyrica and Ambien together?

Absolutely. In fact, this is the best combination for sleep I have had, and I have taken both of these every night for the past 3 years (25mg Seroquel w/10mg Ambien)... I find the ambien relaxes me to where I can lay down and the Seroquel actually shuts my brain down and keeps me asleep. Neither of these work good for me by itself, but combining them works wonderfully.