The Justinian Plague, which began in the 6th century, is believed to have started in the region of Central Asia, spreading through trade routes, particularly via the Silk Road. It was caused by the bacterium Yersinia pestis, primarily transmitted through fleas that infested rats. The plague reached the Byzantine Empire around 541 AD, leading to devastating outbreaks that significantly impacted population and society. Its spread was exacerbated by urban overcrowding and the movement of troops and traders.
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