Which description matches the characteristics of clinical depression?

Clinical depression, also known as major depressive disorder, is characterized by persistent feelings of sadness, hopelessness, and a lack of interest or pleasure in most activities. Individuals may experience changes in appetite, sleep disturbances, fatigue, difficulty concentrating, and thoughts of worthlessness or guilt. These symptoms typically last for at least two weeks and significantly impair daily functioning. It is important for those experiencing such symptoms to seek professional help for diagnosis and treatment.