When is the best time of day to take Aleve?

• The Tylenol contains Benadryl, which causes drowsiness. So probably 30 minutes before you go to sleep is a good time to take it.

• Interestingly, as stated above, Tylenol does contain Diphenhydramine HCl (Benadryl), which is used for Allergies, sleep aid, and motion sickness.

only Tylenol pm has benadryl in it. you can take regular Tylenol any time of the day