Why griseofulvin given with fat?

Griseofulvin is given with fat because its absorption in the gastrointestinal tract is significantly enhanced in the presence of dietary fats. The lipid environment increases the solubility of griseofulvin, allowing for better bioavailability and effectiveness in treating fungal infections. This is particularly important since griseofulvin has low water solubility, and taking it with a fatty meal can optimize its therapeutic action.