To change the spare tire on a Lexus RX330, first ensure the vehicle is parked on a flat surface and engage the parking brake. Loosen the lug nuts slightly before lifting the vehicle with the jack, then remove the lug nuts completely and take off the flat tire. Place the spare tire onto the wheel hub, hand-tighten the lug nuts, lower the vehicle back to the ground, and finally tighten the lug nuts in a crisscross pattern to ensure a secure fit.
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