Yes, the 4L60E transmission can be used in both 2-wheel drive (2WD) and 4-wheel drive (4WD) applications. However, the configurations differ slightly; the 4WD version typically includes additional components, such as a transfer case, to facilitate the transfer of power to all four wheels. The 2WD version is designed solely for rear-wheel drive applications. Both versions share many internal components but are tailored for their specific driveline configurations.
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