What are good subjects to argue about on the subject anti-federalist and federalist?

Quite a variety of 'good subjects to argue about' can be found in regard to 'anti-federalist and federalist' matters. Put in question-form, two of the most important (and controversial) are the following: First, at what point does federal power move from 'reasonable' to 'tyrannical'? Second, do states have the right to secede from the Union?